Metabolic
MOTS-C 10mg
10MG · lyophilized
Order & shipping details
Quantity breaks: 5 = −10% · 10 = −15%. Bulk pricing at qty ≥ 10.
- Typically ships the same business day — orders before 3:00 PM PST
- Discreet packaging — nothing on the outside
- Arrived damaged? Contact support — we'll help
View certificate of analysis →
On the record
This Lot's Certificate of Analysis
The certificate below is the one issued for the lot printed on the vial. Read it in full, or look it up at the lab that ran it.
MOTS-C 10mg
Lot VR0304260110 · HPLC purity 99.07% · Vanguard Laboratory · report V260407-4 004 · reported 16 Apr 2026
What this is
A 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene.
That sentence contains the single most interesting fact about MOTS-c, so let us slow down on it. Almost every peptide in this catalog is encoded in nuclear DNA — the genome in the cell's nucleus. MOTS-c is not. It is encoded inside the mitochondrial genome, a small separate loop of DNA that mitochondria carry from their own evolutionary history. A short open reading frame tucked inside the 12S ribosomal RNA gene codes for this 16-amino-acid peptide.
Peptides encoded this way are called mitochondrial-derived peptides, and there are only a handful of confirmed ones. We stock two: MOTS-c and Humanin, which comes out of the 16S rRNA gene instead. If you are working on mitochondrial signalling, those two are usually studied as a set.
This is the 10mg vial. There are also 20mg and 40mg fills of the same compound.
Research profile
Studied in metabolic and mitochondrial research as a model for AMPK-pathway signaling and cellular energy regulation.
AMPK is a cellular energy sensor — the enzyme complex that reads the ratio of spent to unspent energy currency in the cell and shifts metabolic behaviour accordingly. It is one of the most-studied nodes in metabolic biology, and MOTS-c is frequently used as a probe for it.
The broader research framing here is retrograde signalling: the idea that mitochondria do not only take instructions from the nucleus but send signals back. MOTS-c is one of the molecules used to investigate that direction of traffic, which is why the literature clusters around cellular energy regulation rather than any single organ or tissue.
Research on mitochondrial-derived peptides is comparatively young — MOTS-c was first described in 2015 — so the body of work is thinner than for, say, BPC-157. That is a reason to read closely, not a reason to avoid it. It also means most of what exists is in-vitro and animal work.
Specifications
| Property | This lot |
|---|---|
| Compound | MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) |
| CAS | 1627580-64-6 |
| Sequence length | 16 amino acids |
| Labelled mass | 10mg |
| Certified quantity (this lot) | 11.01 mg |
| Chromatographic purity | 99.07 Area%, HPLC-UV/VIS |
| Endotoxin | <5.00 EU/mg (LAL) |
| Physical form | Lyophilized powder |
| Storage (unopened) | −20°C |
| Reconstitution | Bacteriostatic water — see the reference calculator on this page |
| Lot | VR0304260110 |
| Laboratory ID | V260407-4 004 |
Lab testing and this lot's certificate
Lot VR0304260110 was tested by Vanguard Laboratory, independent and A2LA-accredited (A2LA certificate #6377.01.01). The certificate is published — you can open the PDF from this page without asking anyone.
- Chromatographic purity: 99.07 Area% by HPLC-UV/VIS. Above our 98.0 Area% pass threshold.
- Quantity: 11.01mg against a 10mg label — overfill, which passes.
- Endotoxin: <5.00 EU/mg by LAL.
Reported by Dustin Newman, Laboratory Director; approved by Tori Johnson, Operations Manager. The certificate relates only to the lot tested.
The 20mg and 40mg fills carry their own separate certificates — V260407-4 005 and V260407-4 006. Same compound, different lots, different documents. We do not reuse a certificate across fills, because a certificate that covers a mass it was not run against is not a certificate.
Look up any lot on the lab tests page →
Handling and storage
Lyophilized. Reconstitute with bacteriostatic water; store at minus 20C.
Standard peptide handling: sealed powder at −20°C, ambient-temperature shipping is fine, care starts at reconstitution. The reconstitution reference on this page will give you the resulting concentration for any diluent volume you choose.
That reference is for in-vitro laboratory handling only. Its outputs describe the physical properties of the reconstituted vial — concentration and mass drawn — and are not dosing guidance, administration instructions, or medical advice.
Bacteriostatic water is sold separately.
Questions
What does "mitochondrial-derived" actually mean?
The gene that codes for MOTS-c sits in the mitochondrial genome, not the nuclear genome. Mitochondria carry their own small circle of DNA, and this peptide is encoded inside the 12S rRNA gene on it.
Is MOTS-c related to Humanin?
They are siblings in the same small family. Humanin is also a mitochondrial-derived peptide, encoded in the 16S rRNA gene instead of the 12S. Researchers working on mitochondrial signalling usually look at both.
Which category does MOTS-c sit in?
Metabolic. It is a mitochondrial-derived peptide studied in metabolic and mitochondrial research, so that is where it sits in our catalog. It has nothing to do with incretin receptors.
Do the 10mg, 20mg and 40mg vials share a certificate?
No. Each fill is a separate lot with its own Vanguard certificate and its own Laboratory ID.
Purity is 99.07% here but 99.8% on some other products. Is that a problem?
No. Both clear the 98.0 Area% threshold comfortably. Purity varies lot to lot; that is exactly why we publish the number per lot rather than printing one figure across the catalog.
Research Use Only. This product is sold for in-vitro research use only. It is not a drug, not a supplement, and not for human or veterinary use. Hello Stacks makes no claims regarding the safety, efficacy or suitability of any compound for any use, and publishes no dosing guidance.